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KMID : 0861020110260010059
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Korea Journal of Herbology
2011 Volume.26 No. 1 p.59 ~ p.63
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Effects of Astragali Radix Extracts on the Elastase Activity and DPPH and NO Scavenging Activities
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Mou Chong-Jeong
Lee Se-Na
Kim Myung-Gyou
Kim Myoung-Hee
Kim Hyung-Jun
Jo Hak-Jun
Leem Kang-Hyun
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Abstract
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Objectives: Elastic fibers are found in the skin, lungs, arteries, veins and other structures. The defects of elastic matrix aggravate hypertension which is associated with alteration in the great arteries, arteries, and arterioles. The elastase inhibitors were undergoing in clinical studies about emphysema and pulmonary hypertension. This study was designed to investigate the effect of Astragali Radix extracts (AR) on elastase activity and anti-oxidative effects.
Methods:The elastase inhibitory activity and DPPH (1,1-diphenyl-2-picrylhydrazyl) and NO free radical scavenging activities of AR were measured.
Results: The elastase activity was significantly inhibited by AR. The significant DPPH and NO free radical scavenging activities were observed in AR as well.
Conclusion: AR showed the anti-elastase effects and anti-oxidative activities in vitro. These results suggest that AR may be a possible drug for the treatment of pulmonary emphysema and pulmonary hypertension.
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KEYWORD
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Astragali Radix, elastase, DPPH, NO
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